E2F4 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-E2F4 full-length
Host
Human
Theoretical MW (kDa)
44
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-E2F4 antibody (H00001874-D01P) by Western Blots.
SDS-PAGE Gel
E2F4 transfected lysate.
Western Blot
Lane 1: E2F4 transfected lysate ( 44.00 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — E2F4
Entrez GeneID
1874GeneBank Accession#
NM_001950.3Protein Accession#
NP_001941.2Gene Name
E2F4
Gene Alias
E2F-4
Gene Description
E2F transcription factor 4, p107/p130-binding
Omim ID
600659Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq
Other Designations
E2F transcription factor 4|p107/p130-binding protein
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