DUT MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of DUT expression in transfected 293T cell line (H00001854-T01) by DUT MaxPab polyclonal antibody.
Lane 1: DUT transfected lysate(26.60 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of DUT transfected lysate using anti-DUT MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with DUT purified MaxPab mouse polyclonal antibody (B01P) (H00001854-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human DUT protein.
Immunogen
DUT (NP_001020419.1, 1 a.a. ~ 252 a.a) full-length human protein.
Sequence
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of DUT expression in transfected 293T cell line (H00001854-T01) by DUT MaxPab polyclonal antibody.
Lane 1: DUT transfected lysate(26.60 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of DUT transfected lysate using anti-DUT MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with DUT purified MaxPab mouse polyclonal antibody (B01P) (H00001854-B01P). -
Gene Info — DUT
Entrez GeneID
1854GeneBank Accession#
NM_001025248Protein Accession#
NP_001020419.1Gene Name
DUT
Gene Alias
FLJ20622, dUTPase
Gene Description
deoxyuridine triphosphatase
Omim ID
601266Gene Ontology
HyperlinkGene Summary
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq
Other Designations
dUTP nucleotidohydrolase|dUTP pyrophosphatase|deoxyuridine 5'-triphosphate nucleotidohydrolase
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Interactome
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Pathway
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Disease
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