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DUSP8 Pre-design Chimera RNAi

  • Catalog # : H00001850-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens dual specificity phosphatase 8 (DUSP8), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_004420
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 1850
  • Gene Name:
  • DUSP8
  • Gene Alias:
  • C11orf81,FLJ42476,FLJ42958,HB5,HVH-5,HVH8
  • Gene Description:
  • dual specificity phosphatase 8
  • Gene Summary:
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq
  • Other Designations:
  • H1 phosphatase, vaccinia virus homolog,serine/threonine specific protein phosphatase
  • Gene Pathway
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