Products

Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

DUSP4

Gene Alias

HVH2, MKP-2, MKP2, TYP

Gene Description

dual specificity phosphatase 4

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq

Other Designations

MAP kinase phosphatase 2|VH1 homologous phosphatase 2|serine/threonine specific protein phosphatase