DUSP4 monoclonal antibody (M01), clone 3D6-G6
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More Files
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Western Blot (Cell lysate)
DUSP4 monoclonal antibody (M01), clone 3D6-G6 Western Blot analysis of DUSP4 expression in HeLa ( Cat # L013V1 ).
Western Blot detection against Immunogen (69.08 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant DUSP4.
Immunogen
DUSP4 (AAH02671, 1 a.a. ~ 394 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (95); Rat (96)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (69.08 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
DUSP4 monoclonal antibody (M01), clone 3D6-G6 Western Blot analysis of DUSP4 expression in HeLa ( Cat # L013V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — DUSP4
Entrez GeneID
1846GeneBank Accession#
BC002671Protein Accession#
AAH02671Gene Name
DUSP4
Gene Alias
HVH2, MKP-2, MKP2, TYP
Gene Description
dual specificity phosphatase 4
Omim ID
602747Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq
Other Designations
MAP kinase phosphatase 2|VH1 homologous phosphatase 2|serine/threonine specific protein phosphatase
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Interactome
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Pathway
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Publication Reference
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Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer.
Lee JU, Huang S, Lee MH, Lee SE, Ryu MJ, Kim SJ, Kim YK, Kim SY, Joung KH, Kim JM, Shong M, Jo YS.
European Journal of Endocrinology 2012 Apr; 167(1):93.
Application：IHC-P, Human, Human papillary thyroid cancer.
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Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer.
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