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DUSP3 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00001845-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-DUSP3 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 20.46
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-DUSP3 antibody (H00001845-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00001845-T01
    DUSP3 transfected lysate.
    Western Blot
    QC Testing of H00001845-T01
    Lane 1: DUSP3 transfected lysate ( 20.46 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 1845
  • Protein Accession#:
  • -
  • Gene Name:
  • DUSP3
  • Gene Alias:
  • VHR
  • Gene Description:
  • dual specificity phosphatase 3
  • Gene Summary:
  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq
  • Other Designations:
  • serine/threonine specific protein phosphatase,vaccinia virus phosphatase VH1-related
  • Gene Pathway
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