DUSP3 monoclonal antibody (M07), clone 2C4
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More Files
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Specifications
Product Description
Mouse monoclonal antibody raised against a partial recombinant DUSP3.
Immunogen
DUSP3 (NP_004081, 76 a.a. ~ 185 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
NFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (94); Rat (92)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged DUSP3 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — DUSP3
Entrez GeneID
1845GeneBank Accession#
NM_004090Protein Accession#
NP_004081Gene Name
DUSP3
Gene Alias
VHR
Gene Description
dual specificity phosphatase 3
Omim ID
600183Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq
Other Designations
serine/threonine specific protein phosphatase|vaccinia virus phosphatase VH1-related
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Interactomes
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Pathways
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