DSC3 monoclonal antibody (M01), clone 4D2
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant DSC3.
Immunogen
DSC3 (NP_001932, 585 a.a. ~ 684 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
CKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRST
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (74); Rat (69)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged DSC3 is approximately 1ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to DSC3 on A-431 cell. [antibody concentration 10 ug/ml] -
Gene Info — DSC3
Entrez GeneID
1825GeneBank Accession#
NM_001941Protein Accession#
NP_001932Gene Name
DSC3
Gene Alias
CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP
Gene Description
desmocollin 3
Omim ID
600271Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
desmocollin 4
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Interactome
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Disease
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