DSC2 (Human) Recombinant Protein (Q02)
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More Files
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Specification
Product Description
Human DSC2 partial ORF ( NP_077740.1, 444 a.a. - 534 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLD
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.75
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DSC2
Entrez GeneID
1824GeneBank Accession#
NM_024422Protein Accession#
NP_077740.1Gene Name
DSC2
Gene Alias
ARVD11, CDHF2, DG2, DGII/III, DKFZp686I11137, DSC3
Gene Description
desmocollin 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
desmosomal glycoprotein II/III
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Interactome
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Pathway
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Disease
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