SLC26A3 monoclonal antibody (M01), clone 2E3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant SLC26A3.
Immunogen
SLC26A3 (NP_000102, 503 a.a. ~ 600 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
TQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (87); Rat (89)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.52 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to SLC26A3 on formalin-fixed paraffin-embedded human spleen. [antibody concentration 1.8 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SLC26A3 is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — SLC26A3
Entrez GeneID
1811GeneBank Accession#
NM_000111Protein Accession#
NP_000102Gene Name
SLC26A3
Gene Alias
CLD, DRA
Gene Description
solute carrier family 26, member 3
Omim ID
126650Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq
Other Designations
down-regulated in adenoma protein
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Interactome
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Disease
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Publication Reference
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ION TRANSPORT MECHANISMS LINKED TO BICARBONATE SECRETION IN THE ESOPHAGEAL SUBMUCOSAL GLANDS.
Abdulnour-Nakhoul S, Nakhoul HN, Kalliny MI, Gyftopoulos A, Rabon E, Doetjes R, Brown K, Nakhoul NL.
American Journal of Physiology. Regulatory, Integrative and Comparative 2011 Jul; 301(1):R83.
Application:IHC-Fr, IF, Pig, Pig esophageal submucosal glands.
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ION TRANSPORT MECHANISMS LINKED TO BICARBONATE SECRETION IN THE ESOPHAGEAL SUBMUCOSAL GLANDS.
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