DR1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
DR1 transfected lysate.
Western Blot
Lane 1: DR1 transfected lysate ( 19.47 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-DR1 full-length
Host
Human
Theoretical MW (kDa)
19.47
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-DR1 antibody (H00001810-B01) by Western Blots.
SDS-PAGE Gel
DR1 transfected lysate.
Western Blot
Lane 1: DR1 transfected lysate ( 19.47 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — DR1
Entrez GeneID
1810GeneBank Accession#
NM_001938.2Protein Accession#
NP_001929.1Gene Name
DR1
Gene Alias
NC2, NC2-BETA
Gene Description
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Omim ID
601482Gene Ontology
HyperlinkGene Summary
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq
Other Designations
OTTHUMP00000012556|OTTHUMP00000012557|down-regulator of transcription 1
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Interactome
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Disease
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