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Last updated: 2017/11/19

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DR1 (Human) Recombinant Protein (P01)

  • Catalog # : H00001810-P01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human DR1 full-length ORF ( AAH02809, 1 a.a. - 176 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 45.10
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00001810-P01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Entrez GeneID:
  • 1810
  • Gene Name:
  • DR1
  • Gene Alias:
  • NC2,NC2-BETA
  • Gene Description:
  • down-regulator of transcription 1, TBP-binding (negative cofactor 2)
  • Gene Summary:
  • This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000012556,OTTHUMP00000012557,down-regulator of transcription 1
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