DR1 MaxPab mouse polyclonal antibody (B01)
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More Files
- More Functions
Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in Raw 264.7.
Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in PC-12.
Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in NIH/3T3.
Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in Hela S3 NE.
Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in Jurkat.
Western Blot (Transfected lysate)
Western Blot analysis of DR1 expression in transfected 293T cell line (H00001810-T01) by DR1 MaxPab polyclonal antibody.
Lane 1: DR1 transfected lysate(19.36 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to DR1 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human DR1 protein.
Immunogen
DR1 (NP_001929.1, 1 a.a. ~ 176 a.a) full-length human protein.
Sequence
MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI
Host
Mouse
Reactivity
Human, Mouse, Rat
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in Raw 264.7.Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in PC-12.Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in NIH/3T3.Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in Hela S3 NE.Western Blot (Cell lysate)
DR1 MaxPab polyclonal antibody. Western Blot analysis of DR1 expression in Jurkat.Western Blot (Transfected lysate)
Western Blot analysis of DR1 expression in transfected 293T cell line (H00001810-T01) by DR1 MaxPab polyclonal antibody.
Lane 1: DR1 transfected lysate(19.36 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to DR1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — DR1
Entrez GeneID
1810GeneBank Accession#
NM_001938.2Protein Accession#
NP_001929.1Gene Name
DR1
Gene Alias
NC2, NC2-BETA
Gene Description
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Omim ID
601482Gene Ontology
HyperlinkGene Summary
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq
Other Designations
OTTHUMP00000012556|OTTHUMP00000012557|down-regulator of transcription 1
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Interactome
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Disease
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