DPYD (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human DPYD partial ORF ( NP_000101, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYY
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (88)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DPYD
Entrez GeneID
1806GeneBank Accession#
NM_000110Protein Accession#
NP_000101Gene Name
DPYD
Gene Alias
DHP, DHPDHASE, DPD, MGC132008, MGC70799
Gene Description
dihydropyrimidine dehydrogenase
Omim ID
274270Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000037640|OTTHUMP00000058954|dihydrothymine dehydrogenase|dihydrouracil dehydrogenase
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Interactome
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Pathway
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Disease
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