DPYD monoclonal antibody (M01), clone 7D4
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More Files
- More Functions
Western Blot (Cell lysate)
DPYD monoclonal antibody (M01), clone 7D4. Western Blot analysis of DPYD expression in Hela S3 NE ( Cat # L013V3 ).
Western Blot (Cell lysate)
DPYD monoclonal antibody (M01), clone 7D4 Western Blot analysis of DPYD expression in HeLa ( Cat # L013V1 ).
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged DPYD is approximately 0.1ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to DPYD on HeLa cell. [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (37.84 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant DPYD.
Immunogen
DPYD (NP_000101, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYY
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (88)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
DPYD monoclonal antibody (M01), clone 7D4. Western Blot analysis of DPYD expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Cell lysate)
DPYD monoclonal antibody (M01), clone 7D4 Western Blot analysis of DPYD expression in HeLa ( Cat # L013V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged DPYD is approximately 0.1ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to DPYD on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — DPYD
Entrez GeneID
1806GeneBank Accession#
NM_000110Protein Accession#
NP_000101Gene Name
DPYD
Gene Alias
DHP, DHPDHASE, DPD, MGC132008, MGC70799
Gene Description
dihydropyrimidine dehydrogenase
Omim ID
274270Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000037640|OTTHUMP00000058954|dihydrothymine dehydrogenase|dihydrouracil dehydrogenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.
Kuilenburg AB, Meijer J, Tanck MW, Dobritzsch D, Zoetekouw L, Dekkers LL, Roelofsen J, Meinsma R, Wymenga M, Kulik W, Büchel B, Hennekam RC, Largiadèr CR.
Biochimica et Biophysica Acta 2016 Apr; 1862(4):754.
Application：Dot-Tr, Human, HEK 293 Flp-In cells.
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Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.
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