DOK1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
DOK1 transfected lysate
Western Blot
Lane 1: DOK1 transfected lysate ( 52.4 KDa).
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-DOK1 full-length
Host
Human
Theoretical MW (kDa)
52.4
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-DOK1 antibody (H00001796-B01) by Western Blots.
SDS-PAGE Gel
DOK1 transfected lysate
Western Blot
Lane 1: DOK1 transfected lysate ( 52.4 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — DOK1
Entrez GeneID
1796GeneBank Accession#
NM_001381Protein Accession#
NP_001372Gene Name
DOK1
Gene Alias
MGC117395, MGC138860, P62DOK
Gene Description
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Omim ID
602919Gene Ontology
HyperlinkGene Summary
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. [provided by RefSeq
Other Designations
Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|docking protein 1, 62kD (downstream of tyrosine kinase 1)
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Interactome
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Disease
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