Immunoprecipitation of DNASE2 transfected lysate using anti-DNASE2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with DNASE2 purified MaxPab mouse polyclonal antibody (B01P) (H00001777-B01P).
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq
DNase II alpha,DNase II, lysosomal,R31240_2,acid DNase