DNASE1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Western Blot
Lane 1: DNASE1 transfected lysate ( 31.4 KDa)
Lane 2: Non-transfected lysate.
SDS-PAGE Gel
DNASE1 transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-DNASE1 full-length
Host
Human
Theoretical MW (kDa)
31.13
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-DNASE1 antibody (H00001773-B01) by Western Blots.
Western Blot
Lane 1: DNASE1 transfected lysate ( 31.4 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
DNASE1 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — DNASE1
Entrez GeneID
1773GeneBank Accession#
NM_005223Protein Accession#
NP_005214Gene Name
DNASE1
Gene Alias
DKFZp686H0155, DNL1, DRNI, FLJ38093, FLJ44902
Gene Description
deoxyribonuclease I
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
DNase I, lysosomal|Dornase alfa|human urine deoxyribonuclease I
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Interactome
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Disease
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