DMPK purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Cell lysate)
DMPK MaxPab rabbit polyclonal antibody. Western Blot analysis of DMPK expression in PC-12.
Western Blot (Cell lysate)
DMPK MaxPab rabbit polyclonal antibody. Western Blot analysis of DMPK expression in HeLa.
Western Blot (Cell lysate)
DMPK MaxPab rabbit polyclonal antibody. Western Blot analysis of DMPK expression in NIH/3T3.
Western Blot (Transfected lysate)
Western Blot analysis of DMPK expression in transfected 293T cell line (H00001760-T01) by DMPK MaxPab polyclonal antibody.
Lane 1: DMPK transfected lysate(69.40 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human DMPK protein.
Immunogen
DMPK (NP_004400.4, 1 a.a. ~ 629 a.a) full-length human protein.
Sequence
MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
Host
Rabbit
Reactivity
Human, Mouse, Rat
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
DMPK MaxPab rabbit polyclonal antibody. Western Blot analysis of DMPK expression in PC-12.Western Blot (Cell lysate)
DMPK MaxPab rabbit polyclonal antibody. Western Blot analysis of DMPK expression in HeLa.Western Blot (Cell lysate)
DMPK MaxPab rabbit polyclonal antibody. Western Blot analysis of DMPK expression in NIH/3T3.Western Blot (Transfected lysate)
Western Blot analysis of DMPK expression in transfected 293T cell line (H00001760-T01) by DMPK MaxPab polyclonal antibody.
Lane 1: DMPK transfected lysate(69.40 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — DMPK
Entrez GeneID
1760GeneBank Accession#
NM_004409.2Protein Accession#
NP_004400.4Gene Name
DMPK
Gene Alias
DM, DM1, DM1PK, DMK, MDPK, MT-PK
Gene Description
dystrophia myotonica-protein kinase
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq
Other Designations
DM protein kinase|dystrophia myotonica 1|myotonic dystrophy associated protein kinase|myotonic dystrophy protein kinase|myotonin protein kinase A|thymopoietin homolog
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Interactome
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Disease
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