DIO1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human DIO1 partial ORF ( NP_000783.2, 35 a.a. - 125 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
DRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLNFGSCT
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.75
Interspecies Antigen Sequence
Mouse (80); Rat (81)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DIO1
Entrez GeneID
1733GeneBank Accession#
NM_000792Protein Accession#
NP_000783.2Gene Name
DIO1
Gene Alias
5DI, MGC130050, MGC130051, TXDI1
Gene Description
deiodinase, iodothyronine, type I
Omim ID
147892Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq
Other Designations
OTTHUMP00000010105|OTTHUMP00000010106|thyroxine deiodinase type I (selenoprotein)|type-I 5'deiodinase
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Interactome
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Disease
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