DIO1 monoclonal antibody (M01), clone 1E4
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant DIO1.
Immunogen
DIO1 (NP_000783.2, 35 a.a. ~ 125 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
DRVKRNILAMGEKTGMTRNPHFSHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLNFGSCT
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (80); Rat (81)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
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Gene Info — DIO1
Entrez GeneID
1733GeneBank Accession#
NM_000792Protein Accession#
NP_000783.2Gene Name
DIO1
Gene Alias
5DI, MGC130050, MGC130051, TXDI1
Gene Description
deiodinase, iodothyronine, type I
Omim ID
147892Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq
Other Designations
OTTHUMP00000010105|OTTHUMP00000010106|thyroxine deiodinase type I (selenoprotein)|type-I 5'deiodinase
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Interactome
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Disease
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