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Last updated: 2017/8/13

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DHCR24 rabbit monoclonal antibody

  • Catalog # : H00001718-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human DHCR24 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human DHCR24 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human DHCR24 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1718
  • Gene Name:
  • DHCR24
  • Gene Alias:
  • KIAA0018,Nbla03646,SELADIN1,seladin-1
  • Gene Description:
  • 24-dehydrocholesterol reductase
  • Gene Summary:
  • This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq
  • Other Designations:
  • 3 beta-hydroxysterol delta 24-reductase,OTTHUMP00000011685,diminuto/dwarf1 homolog,putative protein product of Nbla03646,selective AD indicator 1
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