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DHCR7 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00001717-T01
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-DHCR7 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 54.5
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-DHCR7 antibody (H00001717-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00001717-T01
    DHCR7 transfected lysate.
    Western Blot
    QC Testing of H00001717-T01
    Lane 1: DHCR7 transfected lysate ( 54.5 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 1717
  • Protein Accession#:
  • -
  • Gene Name:
  • DHCR7
  • Gene Alias:
  • SLOS
  • Gene Description:
  • 7-dehydrocholesterol reductase
  • Gene Summary:
  • This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein
  • Other Designations:
  • delta-7-dehydrocholesterol reductase
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