DGUOK monoclonal antibody (M02), clone 3E9
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant DGUOK.
Immunogen
DGUOK (NP_001920, 1 a.a. ~ 89 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIGLHCPKSWKLAGYDVPGASTMVLHIPDIFLFEPPESTAGALP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (53); Rat (55)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.53 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of DGUOK expression in transfected 293T cell line by DGUOK monoclonal antibody (M02), clone 3E9.
Lane 1: DGUOK transfected lysate(32.056 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
RNAi Knockdown (Antibody validated)
Western blot analysis of DGUOK over-expressed 293 cell line, cotransfected with DGUOK Validated Chimera RNAi ( Cat # H00001716-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with DGUOK monoclonal antibody (M02), clone 3E9 (Cat # H00001716-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control. -
Gene Info — DGUOK
Entrez GeneID
1716GeneBank Accession#
NM_001929Protein Accession#
NP_001920Gene Name
DGUOK
Gene Alias
dGK
Gene Description
deoxyguanosine kinase
Gene Ontology
HyperlinkGene Summary
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000160251|OTTHUMP00000160252|deoxyguanosine kinase, mitochondrial
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Interactome
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Pathway
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Disease
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