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Last updated: 2016/12/4

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DFFB (Human) Recombinant Protein (P01)

  • Catalog # : H00001677-P01
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Human DFFB full-length ORF ( NP_004393.1, 1 a.a. - 338 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • MLQKPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFQLPERGSRLCLYEDGTELTEDYFPSVPDNAELVLLTLGQAWQGYVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQRQRLLADLLHNVSQNIAAETRAEDPPWFEGLESRFQSKSGYLRYSCESRIRSYLREVSSYPSTVGAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRGAKGGSRLCTPEGWFSCQGPFDMDSCLSRHSINPYSNRESRILFSTWNLDHIIEKKRTIIPTLVEAIKEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLNCDPSRIYKPQTRLKRKQPVRKRQ
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 65.5
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00001677-P01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Entrez GeneID:
  • 1677
  • Gene Name:
  • DFFB
  • Gene Alias:
  • CAD,CPAN,DFF-40,DFF2,DFF40
  • Gene Description:
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
  • Gene Summary:
  • Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq
  • Other Designations:
  • DNA fragmentation factor, 40 kD, beta polypeptide,DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase),DNA fragmentation factor, 40 kD, beta subunit,OTTHUMP00000003633,caspase-activated deoxyribonuclease,caspase-activated nuclease
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