DFFB polyclonal antibody (A01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant DFFB.
Immunogen
DFFB (NP_004393, 229 a.a. ~ 338 a.a) partial recombinant protein with GST tag.
Sequence
PFDMDSCLSRHSINPYSNRESRILFSTWNLDHIIEKKRTIIPTLVEAIKEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLNCDPSRIYKPQTRLKRKQPVRKRQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (80); Rat (84)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.21 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
DFFB polyclonal antibody (A01), Lot # 050928JC01. Western Blot analysis of DFFB expression in Daoy.Western Blot (Recombinant protein)
ELISA
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Gene Info — DFFB
Entrez GeneID
1677GeneBank Accession#
NM_004402Protein Accession#
NP_004393Gene Name
DFFB
Gene Alias
CAD, CPAN, DFF-40, DFF2, DFF40
Gene Description
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
Omim ID
601883Gene Ontology
HyperlinkGene Summary
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq
Other Designations
DNA fragmentation factor, 40 kD, beta polypeptide|DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase)|DNA fragmentation factor, 40 kD, beta subunit|OTTHUMP00000003633|caspase-activated deoxyribonuclease|caspase-activated nuclease
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Interactome
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Pathway
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