DFFA (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human DFFA partial ORF ( NP_004392.1, 231 a.a. - 331 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
TSSDVALASHILTALREKQAPELSLSSQDLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQTQSLHSLRSISASKASPPGDLQNPKRARQDPT
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.85
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DFFA
Entrez GeneID
1676GeneBank Accession#
NM_004401Protein Accession#
NP_004392.1Gene Name
DFFA
Gene Alias
DFF-45, DFF1, ICAD
Gene Description
DNA fragmentation factor, 45kDa, alpha polypeptide
Omim ID
601882Gene Ontology
HyperlinkGene Summary
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
DFF45|DNA fragmentation factor, 45 kD, alpha polypeptide|DNA fragmentation factor, 45 kD, alpha subunit|OTTHUMP00000001903|OTTHUMP00000001904
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Interactome
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Disease
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