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DFFA (Human) IP-WB Antibody Pair

  • Catalog # : H00001676-PW2
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  • Specification
  • Product Description:
  • This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Immunoprecipitation-Western Blot (IP-WB)

    QC Testing of H00001676-PW2
    Immunoprecipitation of DFFA transfected lysate using rabbit polyclonal anti-DFFA and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-DFFA.
  • Supplied Product:
  • Antibody pair set content:
    1. Antibody pair for IP: rabbit polyclonal anti-DFFA (300 ul)
    2. Antibody pair for WB: mouse purified polyclonal anti-DFFA (50 ug)
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Applications
  • Application Image
  • Immunoprecipitation-Western Blot
  • Gene Information
  • Entrez GeneID:
  • 1676
  • Gene Name:
  • DFFA
  • Gene Alias:
  • DFF-45,DFF1,ICAD
  • Gene Description:
  • DNA fragmentation factor, 45kDa, alpha polypeptide
  • Gene Summary:
  • Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • DFF45,DNA fragmentation factor, 45 kD, alpha polypeptide,DNA fragmentation factor, 45 kD, alpha subunit,OTTHUMP00000001903,OTTHUMP00000001904
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