DFFA purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
DFFA MaxPab polyclonal antibody. Western Blot analysis of DFFA expression in human liver.
Western Blot (Transfected lysate)
Western Blot analysis of DFFA expression in transfected 293T cell line (H00001676-T01) by DFFA MaxPab polyclonal antibody.
Lane 1: DFFA transfected lysate(36.41 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to DFFA on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human DFFA protein.
Immunogen
DFFA (NP_004392.1, 1 a.a. ~ 331 a.a) full-length human protein.
Sequence
MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNNSDGGTAWISQESFDVDETDSGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQELRQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAAFGEEVDAVDTGISRETSSDVALASHILTALREKQAPELSLSSQDLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQTQSLHSLRSISASKASPPGDLQNPKRARQDPT
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
DFFA MaxPab polyclonal antibody. Western Blot analysis of DFFA expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of DFFA expression in transfected 293T cell line (H00001676-T01) by DFFA MaxPab polyclonal antibody.
Lane 1: DFFA transfected lysate(36.41 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to DFFA on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — DFFA
Entrez GeneID
1676GeneBank Accession#
NM_004401Protein Accession#
NP_004392.1Gene Name
DFFA
Gene Alias
DFF-45, DFF1, ICAD
Gene Description
DNA fragmentation factor, 45kDa, alpha polypeptide
Omim ID
601882Gene Ontology
HyperlinkGene Summary
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
DFF45|DNA fragmentation factor, 45 kD, alpha polypeptide|DNA fragmentation factor, 45 kD, alpha subunit|OTTHUMP00000001903|OTTHUMP00000001904
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Interactome
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Pathway
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Disease
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