AKR1C2 monoclonal antibody (M03A), clone 3C11
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant AKR1C2.
Immunogen
AKR1C2 (AAH63574, 224 a.a. ~ 323 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPVSDEY
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of AKR1C2 expression in transfected 293T cell line by AKR1C2 monoclonal antibody (M03A), clone 3C11.
Lane 1: AKR1C2 transfected lysate(36.7 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — AKR1C2
Entrez GeneID
1646GeneBank Accession#
BC063574Protein Accession#
AAH63574Gene Name
AKR1C2
Gene Alias
AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2
Gene Description
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
Omim ID
600450Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
Other Designations
OTTHUMP00000018995|OTTHUMP00000044759|aldo-keto reductase family 1, member C2|chlordecone reductase homolog|pseudo-chlordecone reductase|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II dihydrodiol dehydrogenase
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Interactome
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Pathway
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Disease
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