AKR1C2 purified MaxPab mouse polyclonal antibody (B02P)
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More Files
- More Functions
Western Blot (Tissue lysate)
AKR1C2 MaxPab polyclonal antibody. Western Blot analysis of AKR1C2 expression in human liver.
Western Blot (Transfected lysate)
Western Blot analysis of AKR1C2 expression in transfected 293T cell line (H00001646-T01) by AKR1C2 MaxPab polyclonal antibody.
Lane 1: AKR1C2 transfected lysate(35.53 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human AKR1C2 protein.
Immunogen
AKR1C2 (AAH07024.1, 1 a.a. ~ 323 a.a) full-length human protein.
Sequence
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
AKR1C2 MaxPab polyclonal antibody. Western Blot analysis of AKR1C2 expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of AKR1C2 expression in transfected 293T cell line (H00001646-T01) by AKR1C2 MaxPab polyclonal antibody.
Lane 1: AKR1C2 transfected lysate(35.53 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — AKR1C2
Entrez GeneID
1646GeneBank Accession#
BC007024.1Protein Accession#
AAH07024.1Gene Name
AKR1C2
Gene Alias
AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2
Gene Description
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
Omim ID
600450Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
Other Designations
OTTHUMP00000018995|OTTHUMP00000044759|aldo-keto reductase family 1, member C2|chlordecone reductase homolog|pseudo-chlordecone reductase|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II dihydrodiol dehydrogenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Proteasome inhibitors MG-132 and bortezomib induce AKR1C1; AKR1C3; AKR1B1; and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.
Ebert B, Kisiela M, Wsol V, Maser E.
Chemico-biological Interactions 2011 May; 191(1-3):239.
Application：WB, Human, Caco-2, HT-29, HCT116, SW-480, A-549, PANC-1, A431, HepG2 cells.
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Proteasome inhibitors MG-132 and bortezomib induce AKR1C1; AKR1C3; AKR1B1; and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.
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