AKR1C2 polyclonal antibody (A01)
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More Files
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Western Blot (Cell lysate)
AKR1C2 polyclonal antibody (A01), Lot # CIL0060112QCS1 Western Blot analysis of AKR1C2 expression in HeLa ( Cat # L013V1 ).
Western Blot (Transfected lysate)
Western Blot analysis of AKR1C2 expression in transfected 293T cell line by AKR1C2 polyclonal antibody (A01).
Lane1:AKR1C2 transfected lysate(37 KDa).
Lane2:Non-transfected lysate.
Western Blot detection against Immunogen (37.11 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant AKR1C2.
Immunogen
AKR1C2 (AAH63574, 224 a.a. ~ 323 a.a) partial recombinant protein with GST tag.
Sequence
EEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPVSDEY
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.11 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
AKR1C2 polyclonal antibody (A01), Lot # CIL0060112QCS1 Western Blot analysis of AKR1C2 expression in HeLa ( Cat # L013V1 ).Western Blot (Transfected lysate)
Western Blot analysis of AKR1C2 expression in transfected 293T cell line by AKR1C2 polyclonal antibody (A01).
Lane1:AKR1C2 transfected lysate(37 KDa).
Lane2:Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — AKR1C2
Entrez GeneID
1646GeneBank Accession#
BC063574Protein Accession#
AAH63574Gene Name
AKR1C2
Gene Alias
AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2
Gene Description
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
Omim ID
600450Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
Other Designations
OTTHUMP00000018995|OTTHUMP00000044759|aldo-keto reductase family 1, member C2|chlordecone reductase homolog|pseudo-chlordecone reductase|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II dihydrodiol dehydrogenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis.
Su JG, Liao PJ, Huang MC, Chu WC, Lin SC, Chang YJ.
Toxicology 2007 Dec; 244(2-3):257.
Application：WB, Human, HepG2 cells.
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Molecular Functional analysis of the Tumor Suppressor Gene PDCD4.
Marikkannu Rajeshwari.
FB 12: Chemie und Pharmazie 2006 Dec; [Epub].
Application：WB, Human, HeLa cells.
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Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis.
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