AKR1C1 polyclonal antibody (A01)
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More Files
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Western Blot (Cell lysate)
AKR1C1 polyclonal antibody (A01), Lot # 070510JCS1 Western Blot analysis of AKR1C1 expression in HeLa ( Cat # L013V1 ).
Western Blot detection against Immunogen (38.21 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant AKR1C1.
Immunogen
AKR1C1 (AAH20216, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag.
Sequence
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDY
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (70); Rat (71)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.21 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
AKR1C1 polyclonal antibody (A01), Lot # 070510JCS1 Western Blot analysis of AKR1C1 expression in HeLa ( Cat # L013V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — AKR1C1
Entrez GeneID
1645GeneBank Accession#
BC020216Protein Accession#
AAH20216Gene Name
AKR1C1
Gene Alias
2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DDH, DDH1, H-37, HAKRC, MBAB, MGC8954
Gene Description
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
Omim ID
600449Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
Other Designations
20 alpha-hydroxysteroid dehydrogenase|OTTHUMP00000018992|aldo-keto reductase C|aldo-keto reductase family 1, member C1|chlordecone reductase homolog|dihydrodiol dehydrogenase 1|dihydrodiol dehydrogenase isoform DD1|hepatic dihydrodiol dehydrogenase|trans-
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Interactome
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Pathway
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Disease
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Publication Reference
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Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells.
Park SH, Kim JH, Ko E, Kim JY, Park MJ, Kim MJ, Seo H, Li S, Lee JY.
FASEB Journal 2018 May; [Epub].
Application：WB-Ce, WB-Tr, Human, HCC827 cells.
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Cisplatin resistance in human cervical, ovarian and lung cancer cells.
Chen J, Solomides C, Parekh H, Simpkins F, Simpkins H.
Cancer Chemotherapy and Pharmacology 2015 Jun; 75(6):1217.
Application：WB-Ce, Human, ME180, ME180R, SKOV3, A549, CpV, CpR, 8n9, CT4, ApSR, A8n3 cells.
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Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.
Buytaert E, Matroule JY, Durinck S, Close P, Kocanova S, Vandenheede JR, de Witte PA, Piette J, Agostinis P.
Oncogene 2007 Oct; 27(13):1916.
Application：WB, Human, T24, RT4 cells.
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Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells.
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