Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

DDB2

Gene Alias

DDBB, FLJ34321, UV-DDB2

Gene Description

damage-specific DNA binding protein 2, 48kDa

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq

Other Designations

DDB p48 subunit|UV-damaged DNA-binding protein 2|damage-specific DNA binding protein 2|damage-specific DNA binding protein 2 (48kD)|xeroderma pigmentosum group E protein