DDB2 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human DDB2 full-length ORF ( NP_000098.1, 1 a.a. - 427 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASAMGYHILIWSQEEARTRK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
74.3
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DDB2
Entrez GeneID
1643GeneBank Accession#
NM_000107.1Protein Accession#
NP_000098.1Gene Name
DDB2
Gene Alias
DDBB, FLJ34321, UV-DDB2
Gene Description
damage-specific DNA binding protein 2, 48kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq
Other Designations
DDB p48 subunit|UV-damaged DNA-binding protein 2|damage-specific DNA binding protein 2|damage-specific DNA binding protein 2 (48kD)|xeroderma pigmentosum group E protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair.
Robu M, Shah RG, Purohit NK, Zhou P, Naegeli H, Shah GM.
PNAS 2017 Jul; 114(33):E6847.
Application：Func, Recombinant protein.
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Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair.
Robu M, Shah RG, Petitclerc N, Brindamour J, Kandan-Kulangara F, Shah GM.
PNAS 2013 Jan; 110(5):1658.
Application：IP, SB, Human, GMU-6, XP-E cells.
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Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair.
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