DDB2 monoclonal antibody (M01), clone 1F11
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More Files
- More Functions
Western Blot detection against Immunogen (37.73 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant DDB2.
Immunogen
DDB2 (AAH00093, 1 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAPKKRPETQKTSEIVLRPRNKRSRSPLELEPEAKKLCAKGSGPSRRCDSDCLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAP
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.73 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — DDB2
Entrez GeneID
1643GeneBank Accession#
BC000093Protein Accession#
AAH00093Gene Name
DDB2
Gene Alias
DDBB, FLJ34321, UV-DDB2
Gene Description
damage-specific DNA binding protein 2, 48kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq
Other Designations
DDB p48 subunit|UV-damaged DNA-binding protein 2|damage-specific DNA binding protein 2|damage-specific DNA binding protein 2 (48kD)|xeroderma pigmentosum group E protein
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Interactome
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Pathway
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Disease
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