DDB2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human DDB2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human DDB2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human DDB2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — DDB2
Entrez GeneID
1643GeneBank Accession#
DDB2Gene Name
DDB2
Gene Alias
DDBB, FLJ34321, UV-DDB2
Gene Description
damage-specific DNA binding protein 2, 48kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq
Other Designations
DDB p48 subunit|UV-damaged DNA-binding protein 2|damage-specific DNA binding protein 2|damage-specific DNA binding protein 2 (48kD)|xeroderma pigmentosum group E protein
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