DCX 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
DCX transfected lysate
Western Blot
Lane 1: DCX transfected lysate ( 40 KDa).
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-DCX full-length
Host
Human
Theoretical MW (kDa)
40
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-DCX antibody (H00001641-B01) by Western Blots.
SDS-PAGE Gel
DCX transfected lysate
Western Blot
Lane 1: DCX transfected lysate ( 40 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — DCX
Entrez GeneID
1641GeneBank Accession#
NM_178151Protein Accession#
NP_835364Gene Name
DCX
Gene Alias
DBCN, DC, LISX, SCLH, XLIS
Gene Description
doublecortin
Gene Ontology
HyperlinkGene Summary
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000062892|doublecortex|doublin|lissencephalin-X
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Interactome
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Disease
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