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Last updated: 2017/12/10

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DAG1 Pre-design Chimera RNAi

  • Catalog # : H00001605-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens dystroglycan 1 (dystrophin-associated glycoprotein 1) (DAG1), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_004393
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 1605
  • Gene Name:
  • DAG1
  • Gene Alias:
  • 156DAG,A3a,AGRNR,DAG
  • Gene Description:
  • dystroglycan 1 (dystrophin-associated glycoprotein 1)
  • Gene Summary:
  • Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants
  • Other Designations:
  • alpha-dystroglycan,beta-dystroglycan,dystroglycan 1,dystrophin-associated glycoprotein-1
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