CYP7A1 monoclonal antibody (M01), clone 8F1
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CYP7A1.
Immunogen
CYP7A1 (NP_000771.2, 179 a.a. ~ 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (74); Rat (80)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CYP7A1 is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — CYP7A1
Entrez GeneID
1581GeneBank Accession#
NM_000780.3Protein Accession#
NP_000771.2Gene Name
CYP7A1
Gene Alias
CP7A, CYP7, MGC126826, MGC138389
Gene Description
cytochrome P450, family 7, subfamily A, polypeptide 1
Omim ID
118455Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. [provided by RefSeq
Other Designations
cholesterol 7 alpha-monooxygenase|cholesterol 7-alpha-hydroxylase|cytochrome P450, subfamily VIIA (cholesterol 7 alpha-monooxygenase), polypeptide 1
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Pathway
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Disease
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