CYP3A5 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CYP3A5 full-length
Host
Human
Theoretical MW (kDa)
55.33
Interspecies Antigen Sequence
Mouse (70); Rat (72)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CYP3A5 antibody (H00001577-B01) by Western Blots.
SDS-PAGE Gel
CYP3A5 transfected lysate.
Western Blot
Lane 1: CYP3A5 transfected lysate ( 55.33 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CYP3A5
Entrez GeneID
1577GeneBank Accession#
NM_000777.2Protein Accession#
AAH33862.1Gene Name
CYP3A5
Gene Alias
CP35, P450PCN3, PCN3
Gene Description
cytochrome P450, family 3, subfamily A, polypeptide 5
Gene Ontology
HyperlinkGene Summary
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. [provided by RefSeq
Other Designations
aryl hydrocarbon hydroxylase|cytochrome P-450|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5|flavoprotein-linked monooxygenase|microsomal monooxygenase|niphedipine oxidase|xenobiotic monooxygenase
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