CYP3A4 MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Cell lysate)
CYP3A4 MaxPab rabbit polyclonal antibody. Western Blot analysis of CYP3A4 expression in HepG2.
Western Blot (Transfected lysate)
Western Blot analysis of CYP3A4 expression in transfected 293T cell line (H00001576-T01) by CYP3A4 MaxPab polyclonal antibody.
Lane 1: CYP3A4 transfected lysate(57.30 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of CYP3A4 transfected lysate using anti-CYP3A4 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with CYP3A4 purified MaxPab mouse polyclonal antibody (B01P) (H00001576-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human CYP3A4 protein.
Immunogen
CYP3A4 (AAI01632.1, 1 a.a. ~ 503 a.a) full-length human protein.
Sequence
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Rat (72)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
CYP3A4 MaxPab rabbit polyclonal antibody. Western Blot analysis of CYP3A4 expression in HepG2.Western Blot (Transfected lysate)
Western Blot analysis of CYP3A4 expression in transfected 293T cell line (H00001576-T01) by CYP3A4 MaxPab polyclonal antibody.
Lane 1: CYP3A4 transfected lysate(57.30 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of CYP3A4 transfected lysate using anti-CYP3A4 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with CYP3A4 purified MaxPab mouse polyclonal antibody (B01P) (H00001576-B01P). -
Gene Info — CYP3A4
Entrez GeneID
1576GeneBank Accession#
NM_017460.3Protein Accession#
AAI01632.1Gene Name
CYP3A4
Gene Alias
CP33, CP34, CYP3A, CYP3A3, HLP, MGC126680, NF-25, P450C3, P450PCN1
Gene Description
cytochrome P450, family 3, subfamily A, polypeptide 4
Omim ID
124010Gene Ontology
HyperlinkGene Summary
This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq
Other Designations
P450-III, steroid inducible|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450, subfamily IIIA, polypeptide 4|glucocorticoid-inducible P450|nifedipine o
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Interactome
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Pathway
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Disease
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Publication Reference
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EExtensive protein interactions involving cytochrome P450 3A4: a possible contributor to the formation of a metabolosome.
Fujiwara R, Itoh T.
Pharmacology Research & Perspectives 2014 Oct; 2(5):e00053.
Application：IP, Human, Liver microsomes.
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EExtensive protein interactions involving cytochrome P450 3A4: a possible contributor to the formation of a metabolosome.
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