CYP3A4 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
CYP3A4 MaxPab polyclonal antibody. Western Blot analysis of CYP3A4 expression in human liver.
Western Blot (Cell lysate)
CYP3A4 MaxPab polyclonal antibody. Western Blot analysis of CYP3A4 expression in HepG2.
Western Blot (Transfected lysate)
Western Blot analysis of CYP3A4 expression in transfected 293T cell line (H00001576-T01) by CYP3A4 MaxPab polyclonal antibody.
Lane 1: CYP3A4 transfected lysate(55.33 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to CYP3A4 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human CYP3A4 protein.
Immunogen
CYP3A4 (AAI01632.1, 1 a.a. ~ 503 a.a) full-length human protein.
Sequence
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (72)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
CYP3A4 MaxPab polyclonal antibody. Western Blot analysis of CYP3A4 expression in human liver.Western Blot (Cell lysate)
CYP3A4 MaxPab polyclonal antibody. Western Blot analysis of CYP3A4 expression in HepG2.Western Blot (Transfected lysate)
Western Blot analysis of CYP3A4 expression in transfected 293T cell line (H00001576-T01) by CYP3A4 MaxPab polyclonal antibody.
Lane 1: CYP3A4 transfected lysate(55.33 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to CYP3A4 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] -
Gene Info — CYP3A4
Entrez GeneID
1576GeneBank Accession#
NM_017460.3Protein Accession#
AAI01632.1Gene Name
CYP3A4
Gene Alias
CP33, CP34, CYP3A, CYP3A3, HLP, MGC126680, NF-25, P450C3, P450PCN1
Gene Description
cytochrome P450, family 3, subfamily A, polypeptide 4
Omim ID
124010Gene Ontology
HyperlinkGene Summary
This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq
Other Designations
P450-III, steroid inducible|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450, subfamily IIIA, polypeptide 4|glucocorticoid-inducible P450|nifedipine o
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Interactome
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Disease
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Publication Reference
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Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis.
Yongdong Niu, Shaohua Fan, Qin Luo, Liming Chen, Danmei Huang, Wenjun Chang, Wenxin Qin, Ganggang Shi.
Journal of Clinical and Translational Hepatology 2021 Aug; 9(4):466.
Application：IHC-P, Human, Mouse, Human hepatocellular carcinoma, Human tissue microarray, Mouse liver.
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Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function.
Alison E Fohner, Rachel Dalton, Kasse Skagen, Konner Jackson, Katrina G Claw, Scarlett E Hopkins, Renee Robinson, Burhan A Khan, Bhagwat Prasad, Erin G Schuetz, Deborah A Nickerson, Timothy A Thornton, Denise A Dillard, Bert B Boyer, Kenneth E Thummel, Erica L Woodahl.
Clinical and Translational Science 2021 Ju; 14(4):1292.
Application：WB-Ce, Human, Human lymphoblastoid cell lines (LCLs).
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Dermal Xenobiotic Metabolism: A Comparison between Native Human Skin, Four in vitro Skin Test Systems and a Liver System.
Wiegand C, Hewitt NJ, Merk HF, Reisinger K.
Skin Pharmacology and Physiology 2014 Jun; 27(5):263.
Application：WB-Ce, Human, HepG2, Fibroblasts, Keratinocytes cells.
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Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line.
Fahrmayr C, Konig J, Auge D, Mieth M, Munch K, Segrestaa J, Pfeifer T, Treiber A, Fromm MF.
British Journal of Pharmacology 2013 May; 169(1):21.
Application：WB-Tr, Dog, MDCKII cell.
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Oncostatin M Renders Epithelial Cell Adhesion Molecule-Positive Liver Cancer Stem Cells Sensitive to 5-Fluorouracil by Inducing Hepatocytic Differentiation.
Yamashita T, Honda M, Nio K, Nakamoto Y, Yamashita T, Takamura H, Tani T, Zen Y, Kaneko S.
Cancer Research 2010 Jun; 70(11):4687.
Application：IHC-P, Mouse, Mouse xenograft tumors.
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Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis.
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