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Last updated: 2017/11/12

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CYP2D6 rabbit monoclonal antibody

  • Catalog # : H00001565-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human CYP2D6 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human CYP2D6 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human CYP2D6 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1565
  • Gene Name:
  • CYP2D6
  • Gene Alias:
  • CPD6,CYP2D,CYP2D@,CYP2DL1,MGC120389,MGC120390,P450-DB1,P450C2D,P450DB1
  • Gene Description:
  • cytochrome P450, family 2, subfamily D, polypeptide 6
  • Gene Summary:
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • cytochrome P450 2D6,cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6,cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1,debrisoquine 4-hydroxylase,flavoprotein-linked monooxygen
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