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CYP2A6 (Human) Recombinant Protein (Q01)

  • Catalog # : H00001548-Q01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human CYP2A6 partial ORF ( AAH28215, 395 a.a. - 494 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 36.74
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00001548-Q01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Entrez GeneID:
  • 1548
  • Gene Name:
  • CYP2A6
  • Gene Alias:
  • CPA6,CYP2A,CYP2A3,P450C2A,P450PB
  • Gene Description:
  • cytochrome P450, family 2, subfamily A, polypeptide 6
  • Gene Summary:
  • This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq
  • Other Designations:
  • coumarin 7-hydroxylase,cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 3,cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6,flavoprotein-linked monooxygenase,xenobiotic monooxygenase
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