CYP1A2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-CYP1A2 full-length
Host
Human
Theoretical MW (kDa)
56.87
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-CYP1A2 antibody (H00001544-B01) by Western Blots.
SDS-PAGE Gel
CYP1A2 transfected lysate.
Western Blot
Lane 1: CYP1A2 transfected lysate ( 56.87 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — CYP1A2
Entrez GeneID
1544GeneBank Accession#
BC067427.1Protein Accession#
-Gene Name
CYP1A2
Gene Alias
CP12, P3-450, P450(PA)
Gene Description
cytochrome P450, family 1, subfamily A, polypeptide 2
Omim ID
124060Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq
Other Designations
P450 form 4|aryl hydrocarbon hydroxylase|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2|dioxin-inducible P3-450|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Adenoma
- Amyotrophic lateral sclerosis
- Arrhythmia
- Arthritis
- Asthma
- Attention
- Breast cancer
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