CYBB (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human CYBB partial ORF ( AAH32720, 120 a.a. - 171 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
LFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
31.46
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CYBB
Entrez GeneID
1536GeneBank Accession#
BC032720Protein Accession#
AAH32720Gene Name
CYBB
Gene Alias
CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX
Gene Description
cytochrome b-245, beta polypeptide
Gene Ontology
HyperlinkGene Summary
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq
Other Designations
OTTHUMP00000031915|cytochrome b-245 beta polypeptide
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Interactome
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