CTNS purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human CTNS protein.
Immunogen
CTNS (AAH32850.1, 1 a.a. ~ 400 a.a) full-length human protein.
Sequence
MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEITFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVITWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKRPGLQAARTGSGSRLRQDWAPSLQPKALPQTTSVSASSLKG
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
CTNS MaxPab rabbit polyclonal antibody. Western Blot analysis of CTNS expression in human stomach.Western Blot (Transfected lysate)
Western Blot analysis of CTNS expression in transfected 293T cell line (H00001497-T01) by CTNS MaxPab polyclonal antibody.
Lane 1: CTNS transfected lysate(45.10 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — CTNS
Entrez GeneID
1497GeneBank Accession#
NM_001031681.1Protein Accession#
AAH32850.1Gene Name
CTNS
Gene Alias
CTNS-LSB, PQLC4
Gene Description
cystinosis, nephropathic
Gene Ontology
HyperlinkGene Summary
This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line.
Sumayao R, McEvoy B, Martin-Martin N, McMorrow T, Newsholme P.
Experimental Physiology 2013 Oct; 98(10):1505.
Application:WB-Tr, Human, HK-2 cells.
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Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line.
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