Products

Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

NKX2-5

Gene Alias

CHNG5, CSX, CSX1, NKX2.5, NKX2E, NKX4-1

Gene Description

NK2 transcription factor related, locus 5 (Drosophila)

Omim ID

Gene Ontology

Gene Summary

Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development (Shiojima et al., 1995 [PubMed 7665173]). It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.[supplied by OMIM

Other Designations

NK2 transcription factor homolog E|NK2 transcription factor related, locus 5|cardiac-specific homeo box|tinman paralog