Products

Western Blot (Transfected lysate)

Western Blot analysis of CRYBB2 expression in transfected 293T cell line by CRYBB2 monoclonal antibody (M02), clone 1F1.

Lane 1: CRYBB2 transfected lysate (Predicted MW: 23.4 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged CRYBB2 is 3 ng/ml as a capture antibody.

ELISA

Entrez GeneID

1415

GeneBank Accession#

NM_000496.2

Protein Accession#

NP_000487.1

Gene Name

CRYBB2

Gene Alias

CCA2, CRYB2, CRYB2A, D22S665

Gene Description

crystallin, beta B2

Omim ID

123620 601547 604307 607133

Gene Ontology

Hyperlink

Gene Summary

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts. [provided by RefSeq

Other Designations

OTTHUMP00000028560|eye lens structural protein